Before Aston Villa and Manchester United face off at 17:30 on Saturday evening, there are three Premier League encounters taking place at 15:00, including relegation battles at St James’ Park and Carrow Road.
We start off on Tyneside with the huge relegation clash between Newcastle United, 19th in the standings, and 17th-place Watford, who are just two points ahead of the Magpies.
Eddie Howe’s men suffered an embarrassing 1-0 defeat to Cambridge United in the FA Cup third round last time out and the former Bournemouth boss will be demanding a response from his side, who would jump out of the bottom three with a win.
Newcastle are expected to hand January arrival Chris Wood, who joined in a £25million deal after the release clause was met in his Burnley contract, a debut, while Kieran Trippier is set to make his league bow for the north-east outfit.
Watford have lost their last seven matches across all competitions and they are without Imran Louza, Adam Masina and William Troost-Ekong, who are all at AFCON, while Emmanuel Dennis, Kiko Femenia, Ben Foster and Christian Kabasele face fitness tests.
Rock-bottom Norwich City are also in action at 15:00 when they welcome fellow strugglers Everton to Carrow Road (Norwich 3/1, Draw 5/2, Everton 21/20 – Match Betting).
The Canaries are winless in their last eight league games and have lost their last six top-flight matches, all to nil, leaving the club three points from safety and in a perilous situation.
As for Everton, they have slipped to 15th position after just one win from the last 12 league games and Rafael Benitez will be desperate for his side to ease the pressure on his shoulders.
The other game kicking off at 15:00 is the contest between Wolverhampton Wanderers, who are on a four-game unbeaten run across all competitions, and 12th-place Southampton, who are unbeaten in five.
At 17:30, there is another huge clash as Aston Villa will be hoping to gain revenge for their recent FA Cup exit when they take on Manchester United (Villa 2/1, Draw 5/2, United 29/20 – Match Betting).
The Red Devils managed to squeeze past Villa in the third round of the FA Cup last time out but they will be without Luke Shaw and Scott McTominay due to suspension, although Harry Maguire, Phil Jones, Jadon Sancho and Cristiano Ronaldo are expected to feature.
Villa boss Steven Gerrard could give debuts to new signings Lucas Digne and Philippe Coutinho, but Ashley Young is still nursing a broken toe and John McGinn is banned.