Scottish champions Rangers have been drawn to face German giants Borussia Dortmund (6/1 Europa League outright) in the Europa League knockout play off.
The new format means that teams who finished second in the Europa League groups would be drawn against the eight third-place teams from each Champions League group.
The winners of those ties will go to face the Europa League group winners in what would proceed to be a conventional knockout format from the round of 16.
Rangers (80/1 Europa League outright) finished second in Group A and did enough to hold on after drawing 1-1 with Lyon on Thursday.
They will be hoping to better their last 16 placing from 2020-21 where they were beaten by Slavia Prague over two legs.
Meanwhile, Barcelona are entering unfamiliar territory as they dropped into the Europa League after failing to reach the last 16 for the first time in 17 years.
They have been given a very tough draw with Luciano Spalletti’s high-flying Serie A outfit Napoli (Outright – Barcelona 8/1, Napoli 16/1) set to visit the Nou Camp.
In the Europa Conference League, Brendan Rodgers’ Leicester City will play Denmark’s Randers in the knockout play off – UEFA’s tertiary tournament taking on a similar format to that of the Europa League.
After losing at Napoli on Thursday, the Foxes were relegated to the Conference League where Rodgers admitted he “did not know” what the competition was.
Celtic, in a similar boat to Leicester, will play Norwegian champions Bodo/Glimt in the knockout round.
Finally, Tottenham, who have not yet officially been knocked out of the competition, could face Rapid Vienna in the knockout play off.
Their final group match against Rennes was called off due to a Covid outbreak and UEFA have said that a resolution is yet to be found.
Vitesse Arnhem will be beneficiaries if Tottenham are excluded.