Just one team has a 100% record going into Week Five in the NFL, with the Arizona Cardinals going from outsiders to potential contenders.

The Cardinals, 13/2 to win the NFC Championship, missed out on the play-offs last season and finished with an 8-8 regular season record, but they have a quarterback who is arguably in the top five in the league.

After winning NFL Offensive Rookie of the Year in 2019, Kyler Murray has started this campaign in fine fashion and has thrown nine touchdowns in the first four games.

Arizona face a stiff test of their progress this season, when they welcome San Francisco 49ers to the University of Phoenix Stadium tonight (Money Line – Arizona 4/9, San Francisco 9/5).

The Niners have lost their last two matches, but their two prior victories have both come on the road and have won five of their last seven at the Cardinals.

The visitors should also have QB Jimmy Garoppolo fit after he suffered a calf injury against Seattle last weekend.

Fresh from a win over New England last week, the 4-1 Tampa Bay Buccaneers face a Florida derby on Sunday when they face Miami Dolphins at the Raymond James Stadium (Money Line – Patriots 2/9, Dolphins 17/5).

The defending champions, 6/1 to win the Super Bowl again, have been scoring plenty of points so far this season – racking up 48 in the win over Atlanta and scoring over 30 points in two of their other matches.

In contrast, the 1-4 Dolphins have not scored 30 or more points in any of their matches and went down 0-35 against Buffalo Bills. Tampa to score over 32 points can be backed at 6/4.

Another standout game sees the teams at the top of the AFC North and NFC North go head-to-head, as Cincinnati Bengals and Green Bay Packers meet in Ohio.

Both teams have 3-1 records and we will get a better idea after Sunday as to who are contenders and who are likely to be also rans.

The Bengals QB Joe Burrow threw for 348 yards in the 24-21 win over Jacksonville and with wide receiver Ja’Maar Chase also blowing hot recently. Home advantage could prove crucial and Cincinnati look a tempting prospect at 13/10.

Whenever you bet on American Football, Betfred.