The NFL season reaches week four this weekend, and this weekend’s matches will be dominated by Tom Brady’s return to Foxborough, as the New England Patriots host the Tampa Bay Buccaneers (Patriots 12/5, Buccaneers 1/3 – Money Line).

Brady returns to his former home for the first time since 2020, and he has since guided the Buccaneers to a Super Bowl of their own (Buccaneers 6/1 to win the 2022 Super Bowl).

The NFL veteran comes up against former coach Bill Belichick, and it could end up being one of the biggest games of the season as the seven-time Super Bowl champion tries to silence the Patriots crowd, who cheered him for 20 years.

Brady is set to become the NFL’s all-time passing leader, needing only 68 yards to break Drew Brees’ record, while he can also join Peyton Manning, Brett Favre and Brees as the only starting QBs to defeat all 32 current franchises.

The Pats are 1-2 for the season and they are likely to struggle against Bruce Arians’ team, who can move to 3-1 with a victory.

On Sunday, the Cleveland Browns will tackle Minnesota Vikings in what could be a high-scoring battle (Vikings 20/21, Browns 20/23 – Money Line).

Sam Darnold and the Carolina Panthers will try to move to 4-0 when they face the Dallas Cowboys, while the Kansas City Chiefs take on the Philadelphia Eagles.

Josh Allen will look to throw a passing touchdown for the 15th game in a row for the Buffalo Bills when they do battle with the Houston Texans.

The New York Giants will look for their first win of the season when they take on the New Orleans Saints, while Miami Dolphins square off against Indianapolis Colts.

Both Washington Football Team and Atlanta Falcons will try to improve their 1-2 records as they face-off, but the New York Jets are likely to struggle against the Tennessee Titans.

Chicago Bears meet the winless Detroit Lions, and a cracking game should be on the cards when Arizona Cardinals and Los Angeles Rams do battle – both teams have records of 3-0 (Rams 4/9, Cardinals 9/5 – Money Line).

The San Francisco 49ers clash with the Seattle Seahawks, Baltimore Ravens play the Denver Broncos, and Sunday’s final game sees the Pittsburgh Steelers tackle the Green Bay Packers.

Whenever you bet on NFL, Betfred.

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