The FA Cup fourth round takes place this weekend and there are plenty of intriguing ties coming up, including heavyweight showdowns and potential giant-killings.

Eight ties take place on Saturday, starting with an all-Premier League contest at St Mary’s with Southampton entertaining holders Arsenal (Southampton 21/10, Draw 23/10, Arsenal 13/10 – Match Betting).

Nobody has lifted the cup more times than the Gunners, who claimed their 14th triumph last season, and Mikel Arteta’s current side will head into this one with renewed confidence following a six-game unbeaten run, while they haven’t even conceded a goal in any of their last five matches.

Meanwhile, the Saints are chasing their third successive home win without conceding, as they look to reach the fifth round for just the second time in the last seven years.

Following that tie, there will be six matches at 15:00, where the likes of Brighton, Sheffield United and West Ham will be looking to avoid exiting the competition at the hands of lower league opposition, but it is perhaps the late game on Saturday that could provide the biggest shock.

That match will see League Two promotion-chasers Cheltenham play host to Manchester City at Whaddon Road (Cheltenham 20/1, Draw 17/2, Man City 1/10 – Match Betting).

The Robins are unbeaten in five games, but they face a daunting task when tackling a City side that have won nine matches on the spin and have a manager in Pep Guardiola that takes every competition seriously.

A further five fourth-round ties take place on Sunday and there certainly appears to be plenty of scope for a shock in the early kick-off, with out-of-form Chelsea set to play host to Championship outfit Luton.

Chelsea have fallen well off the pace in the Premier League over recent weeks after winning just two of their last eight top-flight games and defeat to the Hatters on Sunday could spell the end of Frank Lampard’s tenure as manager.

Leicester and Everton will also be involved in potential banana skin ties against Championship clubs on Sunday, with the Foxes facing a testing away trip to Brentford, while the Toffees will host Sheffield Wednesday in a game that feels like an old-school FA Cup fixture.

However, arguably the tie of the round will come at 17:00 on Sunday, with Premier League leaders Manchester United playing host to familiar rivals Liverpool at Old Trafford (Man United 8/5 , Draw 5/2, Liverpool 8/5).

This will be the second meeting between the two sides in the space of seven days following their goalless league draw at Anfield last Sunday. United will approach the big tie with plenty of confidence as they have only lost one of their last 12, while Liverpool, in contrast, have won just once in six and have failed to score in four of those games.

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